Author/Authors :
Maripov, Abdirashit Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Mamazhakypov, Argen Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Sartmyrzaeva, Meerim Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Akunov, Almaz Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Muratali uulu, Kubatbek Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Duishobaev, Melis Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Cholponbaeva, Meerim Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Sydykov, Akylbek Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan , Sarybaev, Akpay Department of Mountain and Sleep Medicine and Pulmonary Hypertension - National Center of Cardiology and Internal Medicine, Bishkek, Kyrgyzstan
Abstract :
Background. Recent studies have reported that obstructive sleep apnea (OSA) patients present alterations in right ventricular (RV)
structure and function.However, large randomized controlled trials evaluating the impact of OSA on the right ventricle are lacking.
Methods. A comprehensive electronic database (PubMed,Web of Science, and Google Scholar) and reference search up to October
30, 2016, was performed. A systematic review and meta-analysis were performed to assess RV structure and function in OSA
patients based on conventional echocardiography and tissue Doppler imaging. Results. Twenty-five studies with 1,503 OSA patients
and 796 controls were included in this study. OSA patients exhibited an increase in RV internal diameter (weighted mean difference
(WMD) (95% confidence intervals (CIs)) 2.49 (1.62 to 3.37); 𝑝 = 0.000) and RV wall thickness (WMD(95% CIs) 0.82 (0.51 to 1.13);
𝑝 = 0.000). Furthermore, OSA patients had a significantly elevated RV myocardial performance index (WMD (95% CI) 0.08 (0.06
to 0.10); 𝑝 = 0.000), decreased RV S’ (WMD (95% CI) −0.95 (−1.59 to −0.32); 𝑝 = 0.003), tricuspid annular plane systolic excursion
(WMD (95% CI) −1.76 (−2.73 to −0.78); 𝑝 = 0.000), and RV fractional area change (WMD (95% CI) −3.16 (−5.60 to −0.73);
𝑝 = 0.011). Conclusion. OSA patients display RV dilatation, increased wall thickening, and altered RV function.
