Title of article :
Clara Cell Protein Expression in Mechanically Ventilated Term and Preterm Infants with Respiratory Distress Syndrome and at Risk of Bronchopulmonary Dysplasia: A Pilot Study
Author/Authors :
Guzmán-Bárcenas, José Department of Perinatal Hematology - Instituto Nacional de Perinatologıa Isidro Espinoza de los Reyes, Mexico , Calderón-Moore, Antonio Neonatal Intensive Care Unit - Hospital Infantil de Mexico, Mexico , Baptista-González, Héctor Department of Perinatal Hematology - Instituto Nacional de Perinatologıa Isidro Espinoza de los Reyes, Mexico , Irles, Claudine Department of Physiology and Cellular Development - Instituto Nacional de Perinatologıa Isidro Espinoza de los Reyes, Mexico
Abstract :
The aim of this pilot study was to determine Clara cell protein (CC16) concentration in bronchoalveolar lavages (BAL) fluid from
full-term and preterm (<37 weeks’ gestational age) neonates requiring respiratory support, having symptoms of neonatal respiratory
distress syndrome, and at risk of bronchopulmonary dysplasia (BPD). We hypothesized that CC16 may be predictive of BPD
diagnosis regardless of gestational age. BAL fluid CC16 was measured by ELISA at birth and at day 7 of life. Both groups that
developed BPD showed significantly decreased BAL fluid CC16 levels compared to those infants that did not develop the disease.
CC16 positively correlated with diagnosis of BPD and negatively with the severity of the disease. These results suggest that BAL fluid
CC16 levels may have a diagnostic value at day 7 for BPD in both term and preterm infants. This study demonstrates the potential
utility of BAL fluid CC16 levels as a biomarker for BPD in term infants.
Keywords :
Protein , Mechanically Ventilated , Preterm Infants , Distress Syndrome
Journal title :
Canadian Respiratory Journal