Author/Authors :
Ho, Ying-Jui Department of Psychology - Chung Shan Medical University Hospital - Chung Shan Medical University, Taiwan , Weng, Jun-Cheng Department of Medical Imaging and Radiological Sciences - Chang Gung University, Taoyuan, Taiwan , Lin, Chih-Li Institute of Medicine - Chung Shan Medical University, Taichung, Taiwan , Shen, Mei-Shiuan Department of Psychology - Chung Shan Medical University Hospital - Chung Shan Medical University, Taiwan , Li, Hsin-Hua Institute of Medicine - Chung Shan Medical University, Taichung, Taiwan , Liao, Wen-Chieh Department of Anatomy - Faculty of Medicine - Chung Shan Medical University - Chung Shan Medical University Hospital, Taiwan
Abstract :
Dementia with Lewy bodies (DLB) is characterized by neuronal deficits and α-synuclein inclusions in the brain. Ceftriaxone (CEF), a β-lactam antibiotic, has been suggested as a therapeutic agent in several neurodegenerative disorders for its abilities to counteract glutamate-mediated toxicity and to block α-synuclein polymerization. By using manganese-enhanced magnetic resonance imaging (MEMRI) and immunohistochemistry, we measured the effects of CEF on neuronal activity and α-synuclein accumulation in the brain in a DLB rat model. The data showed that CEF corrected neuronal density and activity in the hippocampal CA1 area, suppressed hyperactivity in the subthalamic nucleus, and reduced α-synuclein accumulation, indicating that CEF is a potential agent in the treatment of DLB.
Keywords :
Ceftriaxone Treatment , Neuronal Deficits , Histological , MEMRI Study , Rat , Dementia , Lewy Bodies
