Author/Authors :
Zhuo, Zhao Department of Stem Cells and Regenerative Medicine - Key Laboratory of Cell Biology - Chinese Ministry of Public Health and Key Laboratory of Medical Cell Biology, Chinese Ministry of Education - China Medical University, Shenyang, Liaoning, China , Dan, He Department of Stem Cells and Regenerative Medicine - Key Laboratory of Cell Biology - Chinese Ministry of Public Health and Key Laboratory of Medical Cell Biology, Chinese Ministry of Education - China Medical University, Shenyang, Liaoning, China , Gensong, Li Department of Experimental Center of Functional Disciplines - China Medical University - Shenyang, Liaoning, China , Ping, Shi Department of Academician Expert Workstation and Liaoning Province Human Amniotic Membrane Dressings Stem Cells and Regenerative Medicine Engineering Research Center - Shenyang Amnion Biological Engineering Technology Research and Development Center Co., LTD, Shenyang, Liaoning, China , Xining, Pang Department of Stem Cells and Regenerative Medicine - Key Laboratory of Cell Biology - Chinese Ministry of Public Health and Key Laboratory of Medical Cell Biology, Chinese Ministry of Education - China Medical University, Shenyang, Liaoning, China
Abstract :
Annually, there are many bladder cancer patients undergoing radical cystectomy (RC) with urinary diversion worldwide. Until 2019, intestinal cystoplasty is still the gold standard for bladder replacement, but this therapy is always associated with severe complications. An ideal bladder substitute without using intestinal tissue remains a challenge today. In this work, an artificial mechatronics bladder (AMB) as a brand new bladder replacement approach is developed. We studied the main physiological function characteristics of a natural urinary bladder from teaching books and relevant papers. According to these characteristics, we completed an overall design of AMB and made a prototype in lab. The prototype successfully realized the functions of a natural bladder in vitro. It can expand to store urine in real time when urine is flowing into it. It can send a urination alarm when it is fully filled and can void urine automatically after receiving remote control signals. According to relevant papers and our test experience, if the prototype could be smaller and lighter and manufactured with good biocompatibility materials such as PTFE, we think it is possible for AMB to be implanted in an animal’s body, and we deduce AMB could realize the functions of a natural urinary bladder in vivo. After thorough validation from animal testing, we hope AMB can be a good clinical option for bladder removal patients in the future.
