Author/Authors :
Zhang, Hao Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Han, Yinling Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Jin, Zhangchu Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Ying, Yinghua Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Lan, Fen Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Huang, Huaqiong Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Wang, Shaobin Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Zhou, Hongwei Department of Clinical Laboratory Medicine - Second Affiliated Hospital of Zhejiang University, Hangzhou, China , Zhang, Rong Department of Clinical Laboratory Medicine - Second Affiliated Hospital of Zhejiang University, Hangzhou, China , Hua, Wen Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Shen, Huahao Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Li, Wen Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China , Yan, Fugui Key Laboratory of Respiratory Disease of Zhejiang Province -Department of Respiratory and Critical Care Medicine - Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
Abstract :
Background. Nonresponding pneumonia is responsible for the most mortality of community-acquired pneumonia (CAP).
However, thus far, it is not clear whether viral infection plays an important role in the etiology of nonresponding CAP and
whether there is a significant difference in the clinical characteristics between viral and nonviral nonresponding CAP. Methods.
From 2016 to 2019, nonresponding CAP patients were retrospectively enrolled in our study. All patients received bronchoalveolar
lavage (BAL) and virus detection in BAL fluid by multiplex real-time polymerase chain reaction (PCR), and clinical, laboratory,
and radiographic data were collected. Results. A total of 43 patients were included. 0e median age was 62 years, and 65.1% of
patients were male. Overall, 20 patients (46.5%) were identified with viral infection. Of these viruses, influenza virus (n = 8) and
adenovirus (n = 7) were more frequently detected, and others included herpes simplex virus, human enterovirus, cytomegalovirus,
human coronavirus 229E, rhinovirus, and parainfluenza virus. Compared with nonviral nonresponding CAP, only ground-glass
opacity combined with consolidation was a more common imaging manifestation in viral nonresponding CAP. However, no
obvious differences were found in clinical and laboratory findings between the presence and the absence of viral infections.
Conclusions. Viral infections were particularly frequent in adults with nonresponding CAP. 0e ground-glass opacity combined
with consolidation was a specific imaging manifestation for viral nonresponding CAP, while the clinical and laboratory data
showed no obvious differences between viral and nonviral nonresponding CAP.
