Author/Authors :
Ikenberg, Benno Technical University of Munich - School of Medicine - Klinikum rechts der Isar - Department of Neurology - München, Germany , Schweyer, Kerstin Technical University of Munich - School of Medicine - Klinikum rechts der Isar - Department of Neurology - München, Germany , Seifert, Christian Technical University of Munich - School of Medicine - Klinikum rechts der Isar - Department of Neurology - München, Germany , Fatke, Bastian Technical University of Munich - School of Medicine - Klinikum rechts der Isar - Department of Psychiatry and Psychotherapy - München, Germany , Kreiser, Kornelia Technical University of Munich - School of Medicine - Klinikum rechts der Isar - Department of Neuroradiology - München, Germany , Rabe, Christian Technical University of Munich - School of Medicine - Department of Clinical Toxicology & Poison Control Centre Munich - Klinikum rechts der Isar - München, Germany
Abstract :
Olanzapine is a second-generation antipsychotic drug which is generally considered safe with well therapeutic antipsychotic effects.We describe a patient suffering from bilateral intracerebral hemorrhage after severe olanzapine intoxication without underlyingthrombocytopenia, arterial hypertension, or vascular malformation as cause of intracerebral hemorrhage. This raises thepossibility of a direct side effect of high-dose olanzapine intake. So far, intracranial hemorrhage after olanzapine intoxication insuch constellation has not been reported before. Given the high number of its prescription rates, ourfinding of intracranialhemorrhage after olanzapine intoxication is of high clinical relevance
Keywords :
Bilateral Basal Ganglion Hemorrhage , Severe Olanzapine Intoxication , second-generation antipsychotic drug
