Author/Authors :
Yang, Siyuan Laboratory of Infectious Diseases Center of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Li, Hui Emergency Department of Infectious Diseases of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Tang, Yunxia Laboratory of Infectious Diseases Center of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Yu, Fengting Laboratory of Infectious Diseases Center of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Ma, Chengjie Laboratory of Infectious Diseases Center of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Zhang, Huimin Department of Pediatrics of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Pang, Lin Department of Pediatrics of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Zhao, Hongxin Clinical and Research Center of Infectious Diseases of Beijing Ditan Hospital - Capital Medical University, Beijing, China , Wang, Linghang Laboratory of Infectious Diseases Center of Beijing Ditan Hospital - Capital Medical University, Beijing, China
Abstract :
Background. The FilmArray Respiratory Panel with multiplex targets for respiratory pathogens has been widely used and verified
in clinical trials in special test settings. However, it is necessary to evaluate the panel’s performance at the point of care directly, in
nonspecific test settings. Methods. Patients with respiratory tract infections were enrolled from among emergency department
visitors, and all steps, including the collection of specimens and testing, were performed by our clinicians. Results. Among 270
patients, 196 (72.6%) patients were found to have one or more pathogens. For signal pathogen detection, influenza A virus had the
highest rate of detection; 45 (16.7%) of the patients had two or more respiratory pathogens codetected, and most of the multiplex
pathogens were rhinovirus/enterovirus codetected with Bordetella pertussis (17.8%). The information provided by the FilmArray
had an impact on the prescription of antimicrobials, and there were differences in the rates of antibiotic prescriptions and antiinfluenza prescriptions among patients. Conclusions. Use of the FilmArray by clinical staff was successfully implemented in the
emergency department for the first time in China. The FilmArray has the potential for point-of-care testing in nonspecific settings.
