Title of article :
Isoniazid-Induced Acute Psychosis in a Patient withPleural Tuberculosis
Author/Authors :
Afonso, Hugo Department of Psychiatry and Mental Health - Centro Hospitalar Barreiro-Montijo - Avenida Movimento das Forc ̧as Armadas - Set ́ubal, Portugal , Gomes, Joana Department of Psychiatry and Mental Health - Centro Hospitalar Barreiro-Montijo - Avenida Movimento das Forc ̧as Armadas - Set ́ubal, Portugal , Sousa André Department of Psychiatry and Mental Health - Centro Hospitalar Barreiro-Montijo - Avenida Movimento das Forc ̧as Armadas - Set ́ubal, Portugal , Durães, Diana Department of Psychiatry and Mental Health - Hospital S ̃ao Bernardo - Rua Camilo Castelo Branco , Portugal
Abstract :
Tuberculosis is one of the top 10 causes of death and the leading cause from a single infectious agent (above HIV/AIDS). Isoniazidis highly bactericidal against replicating tubercle bacilli and is a component of all antituberculous chemotherapeutic regimenscurrently recommended by the World Health Organization (WHO). Several neuropsychiatric adverse effects, following boththerapeutic and overdose use of isoniazid, have been described and isoniazid-induced psychosis, although uncommon, has beenreported in the literature. We describe the case of a 21-year-old black woman, with no prior psychiatric history, who developed apsychotic episode four days after she was started on isoniazid. This case highlights psychosis arising as a possible adverse effect ofisoniazid and the importance of remaining vigilant when antituberculous therapy is started.
Keywords :
Isoniazid-Induced , Acute Psychosis , Patient , Pleural Tuberculosis , WHO , HIV / AIDS
Journal title :
Case Reports in Psychiatry
