Tramadol-Induced Mood Elevation in a Patient withNo Previous Psychiatric History

Tramadol is a powerful analgesic medication with antidepressant effects like venlafaxine. Hypomanic features were reported inpatients with psychiatric history of mood disturbance when tramadol was prescribed for them. However, it is extremely rare tonotice such mood-elevating effect in patients who have no previous psychiatric history. We report on the observation of a distressingmood-elevating effect for tramadol in a patient with no previous psychiatric history. We present the case of a 26-year-old femalepatient who developed accelerated flow of speech, overactivity, and difficulty in sleeping following intake of tramadol 50 mg dose.These symptoms resolved four hours later and recurred as she retook tramadol. The patient has no history of mood disorder or anyother psychiatric comorbidity. Clinicians should exercise caution when prescribing tramadol.