Author/Authors :
Guo, Yun Department of Respiratory Medicine - The Affiliated Wuxi Childrens Hospital of Nanjing Medical University, Wuxi, China , Zhang, Xiuqing Department of Respiratory Medicine - Children’s Hospital of Nanjing Medical University, Nanjing, China , Liu, Feng Department of Respiratory Medicine - Children’s Hospital of Nanjing Medical University, Nanjing, China , Li, Ling Department of Respiratory Medicine - The Affiliated Wuxi Childrens Hospital of Nanjing Medical University, Wuxi, China , Zhao, Deyu Department of Respiratory Medicine - Children’s Hospital of Nanjing Medical University, Nanjing, China , Qian, Jun Department of Respiratory Medicine - The Affiliated Wuxi Childrens Hospital of Nanjing Medical University, Wuxi, China
Abstract :
Objective. Asthma and sleep-related breathing disorders (SRBD) are common chronic respiratory diseases in children. The
relationship between asthma and SRDB is bidirectional. However, only a few studies have analyzed the relationship between
asthma control status and risk of SRBD. The aim of this study was to evaluate the relationship between asthma control and SRBD
and further assess the relationship between therapy/atopy/lung function of children with asthma and SRBD. Methods. A total of
209 children aged 3–16 years were enrolled in this study. Pediatric sleep questionnaire (PSQ) scores were used to identify children
at high risk of developing SRBD. Data on asthma control status, therapy, allergy, lung function, and exhaled nitric oxide were
collected. Results. A significantly higher risk of SRBD was found among children with poorly controlled asthma (34.25% vs.
13.97%, P < 0.01) and allergic rhinitis (AR) (34.29% vs. 13.92%, P < 0.01) than among children with well-controlled asthma and
AR. 2e prevalence of SRBD was also significantly higher in asthmatic children with obesity than that with just obesity (42.11% vs.
20.00%, P < 0.05). Multiple logistic regression analysis showed that poorly controlled asthma (OR, 2.746 (95% CI, 1.215–6.209);
P < 0.05) and poorly controlled AR (OR, 3.284 (95% CI, 1.430–7.544); P < 0.01) increased the odds of having SRBD. Conclusion.
Poorly controlled asthma and AR increase the risk of SRBD. A routine check of the level of asthma control and appropriate use of
medication for AR are important because of their influence on SRBD.
