Author/Authors :
Yang, Zhenyu Department of Respiratory and Critical Care Medicine - First Affiliated Hospital of Soochow University, Suzhou, China , Shen, Yinfang Department of Pathology - First Affiliated Hospital of Soochow University, Suzhou, China , Jiang, Junhong Department of Respiratory and Critical Care Medicine - First Affiliated Hospital of Soochow University, Suzhou, China , Liu, Ziyi Department of Respiratory and Critical Care Medicine - First Affiliated Hospital of Soochow University, Suzhou, China , Mu, Chuanyong Department of Respiratory and Critical Care Medicine - First Affiliated Hospital of Soochow University, Suzhou, China
Abstract :
Accumulating evidence shows that histologic transformation is involved in the drug resistance of lung cancer. Moreover, it is
common for lung adenocarcinoma to transform into small-cell lung cancer or squamous cell carcinoma; however, clinical cases
with sarcomatoid transformation have been rarely reported. ,us, both the diagnosis and treatment of lung adenocarcinoma with
sarcomatoid transformation remain difficult. Here, we discuss two patients with lung adenocarcinoma with sarcomatoid
transformation—analyzing the diagnosis, clinical features, immunohistochemical characteristics, therapy, and prognosis—with
the hope that this report will be used as a reference for future treatment of these patients.
