Author/Authors :
Scaffidi, Michael A Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Garg, Ankit Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Ro, Brandon Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Wang, Christopher Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Yang, Tony T. C Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Plener, Ian S Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada , Grin, Andrea Laboratory Medicine and Pathobiology - St. Michael’s Hospital, Toronto, Canada , Colak, Errol Department of Medical Imaging - St. Michael’s Hospital, Toronto, Canada , Grover, Samir C Division of Gastroenterology - St. Michael’s Hospital, Toronto, Canada
Abstract :
Background. Esophageal intramural pseudodiverticulosis (EIPD) is an idiopathic benign chronic disease characterized by flask-like outpouchings of the esophageal wall. It is unknown whether there is a genuine association between EIPD and eosinophilic esophagitis (EoE). Aims. To investigate a possible relationship between EIPD and EoE. Methods. Patients with radiographic or endoscopic evidence of pseudodiverticulosis were identified from the database at a single academic center. Cases were analyzed in three areas: clinical information, endoscopic findings, and course. Results. Sixteen cases of esophageal pseudodiverticulosis were identified. Five patients had histologic evidence of eosinophilic esophagitis. Patients with EoE had pseudodiverticula in the mid-to-distal esophagus while those with EIPD had pseudodiverticula predominantly in the proximal esophagus (p < 0.001). EoE with pseudodiverticulosis occurred in younger patients (p < 0.019). Food bolus obstructions were more common in patients with EoE and pseudodiverticulosis than in EIPD (p < 0.034). Conclusions. This is the first case series supporting a potential association between EoE and pseudodiverticulosis. We also identify characteristic features of pseudodiverticulosis that may raise clinical suspicion of underlying eosinophilic esophagitis.
