Title of article :
Mathematical Model of Three Age-Structured Transmission Dynamics of Chikungunya Virus
Author/Authors :
Agusto, Folashade B Department of Ecology and Evolutionary Biology - University of Kansas - Lawrence, USA , Easley, Shamise Department of Mathematics and Statistics - Austin Peay State University - Clarksville, USA , Freeman, Kenneth Department of Mathematics and Statistics - Austin Peay State University - Clarksville, USA , Thomas, Madison Department of Mathematics and Statistics - Austin Peay State University - Clarksville, USA
Abstract :
We developed a new age-structured deterministic model for the transmission dynamics of chikungunya virus.The model is analyzed
to gain insights into the qualitative features of its associated equilibria. Some of the theoretical and epidemiological findings indicate
that the stable disease-free equilibrium is globally asymptotically stable when the associated reproduction number is less than unity.
Furthermore, the model undergoes, in the presence of disease induced mortality, the phenomenon of backward bifurcation, where
the stable disease-free equilibrium of the model coexists with a stable endemic equilibrium when the associated reproduction
number is less than unity. Further analysis of the model indicates that the qualitative dynamics of the model are not altered by the
inclusion of age structure. This is further emphasized by the sensitivity analysis results, which shows that the dominant parameters
of the model are not altered by the inclusion of age structure. However, the numerical simulations show the flaw of the exclusion
of age in the transmission dynamics of chikungunya with regard to control implementations. The exclusion of age structure fails
to show the age distribution needed for an effective age based control strategy, leading to a one size fits all blanket control for the
entire population.
Keywords :
Mathematical , Transmission , Age-Structured , Chikungunya
Journal title :
Computational and Mathematical Methods in Medicine