Clozapine Can Be the Good Option in Resistant Mania

Bipolar mood disorder is a mental disorder with a lifetime prevalence rate of about 1% in the general population and there are stilla proportion of individuals who suffer from bipolar mood disorders that are resistant to standard treatment. Reporting clozapineresponsive mania that was not responding to two previous consecutive atypical antipsychotics and one typical antipsychotic wasaimed at. A 17-year-old male manic patient was admitted into the psychiatry inpatient department and was nonresponsive toRisperidone 12 mg daily for 4 weeks, Olanzapine 30 mg daily for 3 weeks, and Haloperidol 30 mg daily for 3 weeks, along withvalproate preparation 1500 mg daily. He was started on clozapine as he was nonresponsive to Lithium in previous episodes anddid not consent to starting Electroconvulsive Therapy (ECT). Heresponded adequately to 100 mg clozapine and 1500 mg valproatepreparation and remission happened within 2 weeks of starting clozapine. Clozapine can be a good option for resistant mania andfurther RCT based evidences will strengthen the options in treating resistant mania.