Author/Authors :
Bromis, Konstantinos School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Gkiatis, Kostakis School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Karanasiou, Irene Hellenic Military University - Vari - Athens, Greece , Matsopoulos, George School of Electrical and Computer Engineering - National Technical University of Athens - Athens, Greece , Karavasilis, Eustratios “Evgenidion” General Hospital - Athens, Greece , Papathanasiou, Matilda Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Efstathopoulos, Efstathios Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Kelekis, Nikolaos Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece , Kouloulias, Vasileios Department of Radiology - Radiotherapy Unit - ATTIKON University Hospital - Athens, Greece
Abstract :
Previous studies in small-cell lung cancer (SCLC) patients have mainly focused on exploring neurocognitive deficits associated with
prophylactic cranial irradiation (PCI). Little is known about functional brain alterations that might occur due to chemotherapy
treatment in this population before PCI is administered. For this reason, we used resting-state functional Magnetic Resonance
Imaging (fMRI) to examine potential functional connectivity disruptions in brain networks, including the Default Mode Network
(DMN), the Sensorimotor Network, and the Task-Positive Network (TPN). Nineteen SCLC patients after platinum-based
chemotherapy treatment and thirteen controls were recruited in the current study. ROI-to-ROI and Seed-to-Voxel analyses were
carried out and revealed functional connectivity deficits in patients within all the networks investigated demonstrating the possible
negative effect of chemotherapy in cognitive functions in SCLC populations.
Keywords :
Small-Cell , Brain , Chemotherapy , Resting-State , fMRI
