Inflammatory Myofibroblastic Tumor: A Rare Presentation andan Effective Treatment with Crizotinib

Inflammatory myofibroblastic tumor (IMT) is a rare entity of neoplastic origin. It usually occurs in children and adolescents andmost commonly involves pulmonary and gastrointestinal sites. Here, the authors present two cases; one is the nine months old boywith a subcutaneous IMT in the left temporal region that was treated successfully with surgical resection. To the best of ourknowledge, this is thefirst reported case of a subcutaneous IMT in this particular region. The second is an eight years old girlwith an IMT of the right hemi-pelvis. The mass had complete surgical excision with clear margins and no residual disease. Shewas kept on regular follow-up with ultrasound abdomen. However, her disease relapsed with the appearance of lesions inright iliac fossa, right ovary, and liver. Biopsy of the relapsed abdominal mass confirmed ALK-positive IMT. She wastreated with ALK inhibitor Crizotinib. She was monitored with regular blood complete picture, hepatic and renal functiontest, and ultrasound abdomen. Her lesions started regressing within one month, and she achieved complete remission after6 months of treatment.