Distribution of trace elements like calcium, copper, iron and zinc in serum samples of colon cancer – A case control study

The pathogenesis of a number of diseases like cardiovascular diseases, diabetes and cancer has been associated with changes in the balance of certain trace elements. In the present study we aimed to investigate the levels of trace elements like calcium, copper, iron and zinc in colon cancer patients in comparison with healthy controls. Serum samples were collected from 256 colon cancer patients and 180 healthy age and sex matched controls. Trace element levels were detected using commercially available kits and an Auto-Analyzer (ChemWell 2910, Awareness Technology, and USA). The concentrations of calcium, copper and iron were not significantly different in patients in comparison with healthy controls. The concentration of zinc was significantly lower in colon cancer patients (p=0.001) as compared to normal subjects. Deficiency of zinc may play a role in the development of colon cancer or may contribute to damage already underway. Zn may represent an independent risk factor for colon cancer and therefore a possible target for prevention.