Author/Authors :
Chen, Xi-Zhen Department of Pharmacology - School of Pharmaceutical Sciences - South-Central University for Nationalities, Wuhan, China , Zhang, Wei Kevin Department of Pharmacology - School of Pharmaceutical Sciences - South-Central University for Nationalities, Wuhan, China , Tang, He-Bin Department of Pharmacology - School of Pharmaceutical Sciences - South-Central University for Nationalities, Wuhan, China , Li, Xiao-Jun Department of Pharmacology - School of Pharmaceutical Sciences - South-Central University for Nationalities, Wuhan, China , Tian, Gui-Hua Key Laboratory of Chinese Internal Medicine of MOE - Beijing Dongzhimen Hospital - Beijing University of Chinese Medicine, Beijing, China , Shang, Hong-Cai Key Laboratory of Chinese Internal Medicine of MOE - Beijing Dongzhimen Hospital - Beijing University of Chinese Medicine, Beijing, China , Li, Yu-Sang Key Laboratory of Chinese Internal Medicine of MOE - Beijing Dongzhimen Hospital - Beijing University of Chinese Medicine, Beijing, China
Abstract :
Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2, β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.
Keywords :
Ethanol Supernatant Extracts , Liushenwan Could Alleviate , Nanodiethylnitrosamine-Induced Liver Cancer
