Title of article :
A New Challenging Strategy in the Prevention and Management ofTumor Lysis Syndrome in Patients with Chemo-SensitiveHematological Malignancies
Author/Authors :
ELJack, Ammar Department of Internal Medicine - Beaumont Hospital-Dearborn - Dearborn - MI 48124, USA , El Abdallah, Mohamad Department of Internal Medicine - Beaumont Hospital-Dearborn - Dearborn - MI 48124, USA , Al-Banaa, Kadhim Department of Internal Medicine - Beaumont Hospital-Dearborn - Dearborn - MI 48124, USA , Chaudhry, Kashif Department of Nephrology - Beaumont Hospital-Dearborn - Dearborn - MI, USA , Musa , Faisal Department of Hematology and Oncology - Beaumont Hospital-Dearborn - Dearborn - MI, USA
Abstract :
Tumor lysis syndrome (TLS) is a metabolic derangement that results from rapid destruction of cells. It happensfrequently in cancers receiving chemotherapy, particularly hematological malignancies. It can lead to death in severe cases.Tumor lysis syndrome that leads to acute renal failure requiring dialysis and/or ICU admission can be associated with a higherrate of complications and mortality.Case Report. We present a 24-year-old male patient with Burkitt’s lymphoma. Afterreceiving one cycle therapy, he developed severe kidney injury from TLS. We initiated renal replacement therapy soon after hisadmission to the ICU, with marked response to therapy. This led to early discharge from the ICU.Conclusion. Early initiation ofrenal replacement therapy after TLS-AKI can improve the severity of AKI and hasten recovery and prevent complications. Thiscan lead to earlier discharge from the hospital and better outcomes
Keywords :
Challenging Strategy , Prevention , Management , Tumor Lysis Syndrome , Patients , Chemo-Sensitive Hematological Malignancies , Tumor lysis syndrome (TLS)
Journal title :
Case Reports in Oncological Medicine
