Author/Authors :
Chuang, Jeremy Department of Internal Medicine - Harbor-UCLA Medical Center - Torrance - CA 90509, USA , Uche, An Division of Hematology and Medical Oncology - Harbor-UCLA Medical Center - Torrance - CA 90509, USA , Gupta, Rohan Division of Hematology and Medical Oncology - Harbor-UCLA Medical Center - Torrance - CA 90509, USA , Kim, Phyllis Division of Hematology and Medical Oncology - Harbor-UCLA Medical Center - Torrance - CA 90509, USA , Margolin, Kim Department of Medical Oncology and Therapeutics Research - City of Hope National Medical Center - Duarte - CA 91010, USA
Abstract :
Acute disseminated intravascular coagulation (DIC) is a pathological process involving dysfunction of the coagulation cascade. Inthis case report, we discuss a 33-year-old woman with BRAF V600E-mutated metastatic melanoma who presented in fulminantDIC with concurrent hemorrhagic and thrombotic manifestations and discuss the patient’s brief response to combinationtherapy. In our discussion, we highlight the current understanding of DIC and also identify opportunities for future research toelucidate the genetic aberrations in melanoma that may result in treatment resistance to combination therapy.
Keywords :
Fulminant Disseminated Intravascular Coagulation , Initial Presentation , BRAF-Mutated Melanoma , DIC
