Author/Authors :
Ihimoyan, Ariyo Department of Medicine - Bronxcare Health System - Bronx - New York, USA , Kumar, Kishore Department of Medicine - Bronxcare Health System - Bronx - New York, USA , Tariq, Hassan Department of Medicine - Bronxcare Health System - Bronx - New York, USA , Ahmed, Rafeeq Department of Medicine - Bronxcare Health System - Bronx - New York, USA , Chukwunonso, Chime Department of Medicine - Bronxcare Health System - Bronx - New York, USA , Niazi, Masooma Department of Pathology - Bronxcare Health System - Bronx - New York, USA
Abstract :
The poorly differentiated small-cell type, neuroendocrine carcinoma (NEC) of the gallbladder is a very uncommon subtype of aneuroendocrine tumor of the gastrointestinal tract. Nonsecretory NEC by virtue of its nonspecific and subtle clinicalpresentation of the tumor is usually diagnosed at an advance stage with presenting symptoms related to either locally advancedisease or from metastatic disease. Though the radiologic imaging does identify the gall bladder cancer, the tumor lacks aspecific diagnostic test; therefore, the diagnosis is almost always confirmed on histopathologic and immunohistochemicalstaining. We present a case of a poorly differentiated, small-cell neuroendocrine tumor of the gallbladder. The patient diedwithin 3 months after the definitive diagnosis was made. Survival from this deadly malignancy can be improved with aggressivesurgical treatment followed by chemotherapy and radiotherapy on a case-by-case scenario. The systemic chemotherapyremained the treatment of choice for an unresectable tumor (Chen et al., 2014)
Keywords :
Small-Cell Type , Poorly Differentiated Neuroendocrine Carcinoma , Gallbladder , NEC
