Electrochemotherapy as Promising Treatment Option in RareRecurrent Cutaneous Neoplasm of the Scalp: Case Report of anElderly Patient

Atypicalfibroxanthoma (AFX) is a tumor that commonly presents on the head or neck in older individuals. Making adefinitive diagnosis of AFX is challenging, and frequently, it is hard to distinguish from pleomorphic dermal sarcoma (PDS). Thereare no clear recommendations regarding the treatment of AFX, but an extensive surgery is actually considered the best option.Electrochemotherapy (ECT) is a novel therapeutic modality of local treatment in which the application of electrical pulses,enhancing cell membrane permeability, allows greater intracellular accumulation of chemotherapy drugs in the skin orsubcutaneous tumors.Case Report. We report a case of a 78-year-old male affected by a red, ulcerative, dermal, scalp nodule,which was treated with ECT with a complete clinical response. We have also reported literature data on this topic.Results.Inthis case, ECT showed to be an effective and safe treatment for recurrent neoplasms of the head and neck, considering thecomplete response obtained and the absence of disease relapse after two years.Conclusion. To the best of our knowledge, this isthefirst case report that shows great clinical results using ECT after surgery in relapsed AFX/PDS. However, more studies areneeded to confirm our results