Author/Authors :
Arab, Arman Department of Community Nutrition - School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Rafie, Nahid Department of Clinical Nutrition - School of Nutrition and Food Science, Food Security Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Askari, Gholamreza Department of Community Nutrition - School of Nutrition and Food Science - Food Security Research Center - Isfahan University of Medical Sciences, Isfahan, Iran , Taghiabadi, Mina Department of Nursing and Operating Room - Faculty Member of Neyshabur University of Medical Sciences - Neyshabur University of Medical Sciences, Neyshabur, Iran
Abstract :
Since premenstrual syndrome (PMS) is one of the most common and debilitating disorders in women,
risk factor modification is an urgent health priority. Therefore, this systematic review aimed to
summarize and discuss the outcomes of observational and interventional studies in humans regarding
the relationship between Calcium and PMS. PubMed, Scopus, ISI web of sciences and Google scholar
were searched up to January 2019 to identify relevant studies. The Newcastle‑Ottawa and Jadad
scales were used for quality assessment. A total of 14 studies (8 interventional and 6 observational)
met our inclusion criteria. Majority of the studies showed that not only serum calcium levels are
lower in PMS subjects, but also calcium supplementation could significantly improve the incidence of
PMS and its related symptoms. This systematic review suggests a beneficial role for calcium in PMS
subjects. However, in order to draw a firm link between calcium and PMS, further dose‑response
clinical trials with larger sample size and better methodological design are warranted.
