Title of article :
Beyond the Dual Paraneoplastic Syndromes of Small-CellLung Cancer with ADH and ACTH Secretion: A Case Report withLiterature Review and Future Implications
Author/Authors :
Soe, Myat Han Department of Medicine - Baystate Medical Center - University of Massachusetts Medical School - Springfield - MA, USA , Agarwal, Krishna Adit Department of Medicine - Baystate Medical Center - University of Massachusetts Medical School - Springfield - MA, USA
Abstract :
We present a case of small-cell lung cancer (SCLC) with syndrome of inappropriate antidiuretic hormone secretion (SIADH) inwhich serum sodium gradually normalized with the onset of hypertension, refractory hypokalemia, and chloride-resistantmetabolic alkalosis due to ectopic adrenocorticotrophic hormone (ACTH) secretion (EAS). In this case report, we discuss thediagnostic challenges of dual paraneoplastic syndromes with SIADH and EAS, management of SCLC with paraneoplasticendocrinopathies, and their prognostic impact on SCLC. In addition, we discuss neuroendocrine differentiation and ectopichormone production in relation to intratumoral heterogeneity in SCLC and propose tumor microenvironment and hormonaland metabolic dependence as important determinants of tumor growth and survival
Keywords :
Beyond , Dual Paraneoplastic Syndromes , Small-CellLung Cancer , ADH and ACTH Secretion , SIADH , SCLC , EAS , ACTH
Journal title :
Case Reports in Oncological Medicine
