Title of article :
Malignant Transformation of Testicular Teratoma to PNET,Adenocarcinoma, and Osteosarcoma with Complete Remissionafter Surgery and Combination Chemotherapy in a YoungAdult Male
Author/Authors :
Harrison, Douglas Department of Pediatrics - The University of Texas MD Anderson Cancer Center - Houston - TX, USA , Shaw, Angela Department of Pediatrics - The University of Texas MD Anderson Cancer Center - Houston - TX, USA , Morrell, Miriam Department of Pediatrics - The University of Texas MD Anderson Cancer Center - Houston - TX, USA , Weissferdt, Annikka Department of Pathology - The University of Texas MD Anderson Cancer Center - Houston - TX, USA , Hayes-Jordan, Andrea Department of Surgical Oncology - The University of Texas MD Anderson Cancer Center - Houston - TX, USA
Abstract :
Mixed germ cell tumors (GCT) with teratoma components can transform into somatic malignancies which can include histologiesoutside of traditional germ cell lineages. We describe a case of an 18-year-old man with a metastatic testicular GCT with bothmature and immature teratoma components containing malignant transformation into multiple histologies including PNET inthe primary testicular tumor and osteosarcoma in a separate pulmonary metastatic lesion. Management with targetedchemotherapy resulted in a durable remission. This is thefirst reported case that we know of a patient with primary PNETmalignant transformation with subsequent metastatic transformation to osteosarcoma
Keywords :
Malignant Transformation , Testicular Teratoma , PNET , Adenocarcinoma , Osteosarcoma , Complete Remission , Surgery , Combination Chemotherapy , Young Adult Male
Journal title :
Case Reports in Oncological Medicine
