Author/Authors :
Nascimento Terra Junior, Orlando School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Carvalho Maldonado, Gabriel de School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Rohem Alfradique, Guilherme School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , da Cunha Lisboa, Vinicius School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Arnóbio, Adriano School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Bonfim de Lima, Dirce School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Rachel Diamond, Hilda School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil , Faria Ornellas de Souza, Maria Helena School of Medical Sciences - Rio de Janeiro State University - Professor Manoel de Abreu Avenue 444 - 20550-170 Rio de Janeiro - RJ - Brazil
Abstract :
The NCR receptors play a fundamental role in the cytotoxicity mediated by NK cells against tumor cells. In the current study, we investigated possible HIV/AIDS-related changes in the expression of the NCR receptors comparing healthy donors, HIV/AIDS patients, and HIV/AIDS patients with cancer (HIV/AIDSWC). The NCRs were quantified in NK cells (NKdim and NKbright) and
T lymphocytes from peripheral blood samples by flow cytometry. We found a significant decrease in the frequency of NK cells
expressing NKp46 in HIV/AIDS group (𝑝 = 0.0012). There was a decrease in the frequency of NK cells expressing NKp46 in the
HIV/AIDSWC group; however, this was not statistically significant. We found a significant decrease in the frequency of NK cells
expressing NKp30 in the HIV/AIDS group (𝑝 = 0.0144). There was a decrease in the frequency of NK cells expressing NKp30 and in the HIV/AIDSWC group, but this was not statistically significant. There were no changes in the distribution of NK cells and their subtypes in both groups.
Keywords :
Natural Cytotoxicity Receptors , Patients , HIV/AIDS , Cancer
