Author/Authors :
Ahmadi Vasmehjani, Abbas Department of Virology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Yaghubi, Sajad Department of Clinical Microbiology - Iranshahr University of Medical Sciences, Iranshahr, Iran , Erfani, Yousef Department of Medical Laboratory Sciences - School of Allied Medical Sciences - Tehran University of Medical Sciences, Tehran, Iran , Hajikhezri, Zamaneh Department of Virology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Farahmand, Mohammad Department of Virology - School of Public Health - Tehran University of Medical Sciences, Tehran, Iran , Shayestehpour, Mohammad Department of Microbiology and Immunology - Faculty of Medicine - Kashan University of Medical Sciences, Kashan, Iran , Adeli, Omid Ali Department of Public Health - Lorestan University of Medical Sciences, Khoramabad, Iran , Beiranvand, Maryam Blood Transfusion Research Center - High Institute for Research and Education in Transfusion Medicine, Tehran, Iran
Abstract :
Background: Hepatitis B virus is one of the transfusion transmissible infections. Despite the
availability of hepatitis B virus (HBV) vaccine and screening tests but still danger of virus
transmission via blood transfusion is high in some regions. The objective of this study was to
determine the trend of seroprevalence of hepatitis B in over an 11‑year period (2005–2015).
Methods: In this study, 355,083 blood donors were estimated for hepatitis B surface antigen
(HBs Ag) seropositivity during 2005–2015 who referred to blood infusion centers of Lorestan
province. Third‑generation ELISA method was used to detect HBs Ag. Results: The prevalence
of HBs Ag in blood donors was 0.29% (1017). It was decreased steadily from 2005 to 2015
(0.68% to 0.12%) but increased in 2008 year. The trend prevalence of HBs Ag seropositivity
significantly decreased over the study period (P < 0.001). The decline in HBV infection rates was
more prominent in regular and repeated donor’s groups compared to people who donated blood for
the first time (P < 0.001). Conclusions: The result of present study was indicated, Lorestan city
in west of Iran can be classified as a low‑income region because the low prevalence of HBs Ag in
blood donors. Also the prevalence of HBs Ag in first‑time donors was higher than other groups.
Keywords :
trend , prevalence , Lorestan , hepatitis B , Blood donors
