Author/Authors :
Ghavami, Abed Student Research Committee - Department of Clinical Nutrition - School of Nutrition and Food Science - Isfahan University of Medical Sciences, Isfahan, Iran , Mohammadi, Hamed Department of Community Nutrition - Food Security Research Center - School of Nutrition and Food Sciences - Isfahan University of Medical Sciences, Isfahan, Iran , Hadi, Amir Halal Research Center of IRI, FDA, Tehran, Iran , Ziaei, Rahele Department of Community Nutrition - Food Security Research Center - School of Nutrition and Food Sciences - Isfahan University of Medical Sciences, Isfahan, Iran , Nattagh-Eshtivani, Elyas Student Research Committee - Mashhad University of Medical Sciences, Mashhad, Iran , Veysi Sheykhrobat, Mohammad Student Research Committee - Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran , Askari, Gholamreza Department of Community Nutrition - Food Security Research Center - School of Nutrition and Food Sciences - Isfahan University of Medical Sciences, Isfahan, Iran
Abstract :
Background: Obesity is related to increase in the incidence of morbidity and mortality. Previous
studies have led to conflicting results regarding the effect of coenzyme Q10 (CoQ10) supplementation
on anthropometric indices. This study aimed to evaluate the efficacy of CoQ10 supplementation on
body weight, body mass index (BMI), and waist circumference (WC) through a systematic review
and meta‑analysis of randomized controlled trials (RCTs). Methods: PubMed, Scopus, Web of
Science, and Cochrane Library as well as the reference lists of the identified relevant RCTs were
searched up to March 2019, and weighted mean differences (WMDs) were pooled by using the
random‑effects model. Results: Twenty RCTs (976 participants) were eligible to be included in the
systematic review. The meta‑analysis revealed that CoQ10 supplementation had no effect on body
weight (WMD = −0.04 kg; 95% confidence interval [CI]: −1.96, 1.6; I2 = 0.0%), BMI (WMD =
−0.06 kg/m2; 95% CI: −0.54, 0.42; I2 = 0.0%), and WC (WMD = 0.79 cm; 95% CI: −2.83, 0.04; I2
= 0.0%). Conclusions: CoQ10 supplementation might not improve anthropometric indices. Future
well‑designed trials are still needed to confirm these results.
Keywords :
waist circumference , ubiquinone , meta‑analysis , CoQ10 , body weight , Body mass index
