Primary CNS Burkitt Lymphoma: A Case Report of a 55-Year-OldCerebral Palsy Patient

With primary central nervous system lymphoma (PCNSL) being a rare disease, the subtype of Burkitt lymphoma (BL) presenting asa sole CNS lesion is an even more exceptional diagnosis. A case of coexistent primary CNS Burkitt lymphoma (PCNSBL) withcerebral palsy (CP) is presented. A 55-year-old Caucasian male presented with increasing bilateral lower extremity weaknessabove his baseline in addition to signs of increased intracranial pressure. Four abnormal enhancing masses were detected onMRI with biopsy results consistent with Burkitt lymphoma. Complete staging workup was completed with no evidence of extra-CNS disease noted on PET/CT, bone marrow biopsy, or cerebral spinalfluid analysis. The patient was treated with intravenousas well as intrathecal chemotherapy and found to be in a complete remission at six months. Recurrence in the CNS wasobserved four months later with treatment consisting of whole brain radiation as well as intrathecal chemotherapy. Thirtymonths after diagnosis, the patient remains disease-free. To our knowledge, this is thefirst case of PCNSBL in the setting of CP.A review of literature regarding treatment options in this controversial setting is provided