Author/Authors :
Costa, RubensBarros Division of Hematology and Oncology - Robert H. Lurie Comprehensive Cancer Center - Northwestern University - Chicago - IL , USA , AlBenson, Division of Hematology and Oncology - Robert H. Lurie Comprehensive Cancer Center - Northwestern University - Chicago - IL , USA , Kaplan, Jason B. Division of Hematology and Oncology - Robert H. Lurie Comprehensive Cancer Center - Northwestern University - Chicago - IL , USA , Sadim, Maureen Division of Hematology and Oncology - Robert H. Lurie Comprehensive Cancer Center - Northwestern University - Chicago - IL , USA , Kalyan, Aparna Division of Hematology and Oncology - Robert H. Lurie Comprehensive Cancer Center - Northwestern University - Chicago - IL , USA , Yaghmai, Vahid Department of Radiology - Northwestern University Feinberg School of Medicine - Chicago - IL , USA , Costa, RicardoL.B. Department of Breast Oncology - Lee Moffitt Cancer Center - Moffitt McKinley Outpatient Center - North McKinley Drive,BR-Program - Tampa - FL , USA , Zhou, Haijun Department of Pathology - Northwestern University Feinberg School of Medicine - Chicago - IL , USA , Behdad, Amir Department of Pathology - Northwestern University Feinberg School of Medicine - Chicago - IL , USA , Talamantes, Sarah Northwestern University Feinberg School of Medicine - Chicago - IL , USA
Abstract :
Pancreatic cancer is the fourth most common cancer death in the United States despite comprising a small percentage of the totalnumberofcancercases.)eestimated5-yearoverallsurvival(OS)forpatientswithdistantmetastaticdiseaseisapproximately3%.Newtreatmentoptionsareanunmetneedandremainanareaofactiveinvestigation.A53-year-oldmalewithmetastaticpancreaticcancerpresentedtothehospitalwithacute-on-chronicrespiratoryfailureapproximately24hoursafterreceivinganoveltherapeuticcombination. Chest imaging showed marked changes as concerning for pneumonitis. Infectious workup was negative. )e patienthad initial clinical improvement after receiving initial intravenous steroids and oxygen support but eventually deteriorated lateropting for supportive measures only. With infection ruled out, drug-induced pneumonitis was felt to be the likely cause of theradiologic and clinical changes. )e rapidity of onset of symptoms is the aspect being highlighted in this case.
Keywords :
Extremely Rapid , Pneumonitis , Nivolumab , Pancreatic Adenocarcinoma
