• Title of article

    RecurrentGastrointestinalStromalTumorsintheImatinibMesylateEra:TreatmentStrategiesforanIncurableDisease

  • Author/Authors

    Bowne, WilburB. Department of Surgery - Drexel University College of Medicine - Philadelphia - PA, USA , Platoff, RebeccaM. Department of Surgery - Drexel University College of Medicine - Philadelphia - PA, USA , Morano, WilliamF. Department of Surgery - Drexel University College of Medicine - Philadelphia - PA, USA , Marconcini, Luiz Department of Medicine - Division of Hematology/Oncology - Drexel University College of Medicine - Philadelphia - PA, USA , DeLeo, Nicholas Department of Surgery - Drexel University College of Medicine - Philadelphia - PA, USA , Styler, Michael Department of Surgery - Drexel University College of Medicine - Philadelphia - PA, USA , Mapow, BethL. Department of Pathology and Laboratory Medicine - Drexel University College of Medicine - Philadelphia - PA, USA

  • Pages
    9
  • From page
    1
  • To page
    9
  • Abstract
    Recurrence of gastrointestinal stromal tumors (GISTs) after surgical resection and imatinib mesylate (IM) adjuvanttherapyposesasigni9canttreatmentchallenge.Wepresentthecaseofapatientwhounderwentsurgicalresectionafterrecurrenceandreview the current literature regarding treatment.Case Presentation. A 58-year-old man with a large intra-abdominal jejunal GISTwastreatedwithcompletesurgicalresectionfollowedbyIM..epatientexperienceddiseaserecurrence3.5yearslaterandunderwentIMdoseescalationandreresection.Conclusion.CurrentstrategiestotreatrecurrentGISTincludedoseescalation,modifyingadjuvanttyrosine kinase inhibitor therapy, and surgery. High-level evidence will be required to better de9ne the combinatory roles of tyrosinekinase inhibitor therapy, guided by molecular pro9ling, and surgery in the management of recurrent GIST
  • Keywords
    RecurrentGastrointestinalStromalTumors , ImatinibMesylateEra , TreatmentStrategies , IncurableDisease , Recurrence of gastrointestinal stromal tumors (GISTs)
  • Journal title
    Case Reports in Oncological Medicine
  • Serial Year
    2017
  • Full Text URL
    downloads.hindawi.com/journals/crionm/2017/8349090.pdf
  • Record number

    2611201

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2611201