Author/Authors :
Yankelevich, Maxim Division of Hematology/Oncology - Department of Pediatrics - Children’s Hospital of Michigan - Wayne State University - Detroit - MI , USA , Savasan, Sureyya Division of Hematology/Oncology - Department of Pediatrics - Children’s Hospital of Michigan - Wayne State University - Detroit - MI , USA , Chu, Roland Division of Hematology/Oncology - Department of Pediatrics - Children’s Hospital of Michigan - Wayne State University - Detroit - MI , USA , Dolgopolov, Igor Institute for Pediatric Oncology - N.N. Blokhin Russian Cancer Research Center - 24 Kashirskoye Shosse - Moscow , Russia , Mentkevich, George Institute for Pediatric Oncology - N.N. Blokhin Russian Cancer Research Center - 24 Kashirskoye Shosse - Moscow , Russia
Abstract :
Cumulative myelosuppression is the main limiting factor for administration of repeated cycles of chemotherapy. We presenta case series of 0ve pediatric patients with high-risk solid malignancies who received small split peripheral blood stem cells(PBSC) doses of less than 1×106/kg CD34+cells obtained after a single leukapheresis procedure and given after repeated cyclesof ICE (ifosfamide, carboplatin, and etoposide) chemotherapy. Mean duration to absolute neutrophil count (ANC) recoveryto>1000/mm3and platelet recovery to>50×103/mm3was 17.1 and 24.3 days. Using split doses of PBSC prevented prolongedneutropenia after repeated cycles of submyeloablative chemotherapy.
Keywords :
Small Split Doses , CD34+Peripheral Blood Stem Cells , Support Repeated Cycles , Nonmyeloablative Chemotherapy , ANC , PBSC
