Author/Authors :
Poudel, Dilli Ram Department of Medicine - Reading Hospital - West Reading - PA , USA , Basnet, Sijan Department of Medicine - Reading Hospital - West Reading - PA , USA , Lin, Catherine Department of Medicine - Reading Hospital - West Reading - PA , USA , Dhital, Rashmi Department of Medicine - Reading Hospital - West Reading - PA , USA , Mir, Izza Department of Medicine - Reading Hospital - West Reading - PA , USA , Mohanty, Elan Department of Medicine - Reading Hospital - West Reading - PA , USA , Ghimire, Sushil Department of Medicine - Reading Hospital - West Reading - PA , USA , Tharu, Biswaraj Maharajgunj Medical Campus - Tribhuvan University - Kathmandu, Nepal
Abstract :
Wepresenta caseof a79-year-old malewhopresented withretroperitonealhematoma aweekafter motorvehicle accident.Priorhistoryandfamilyhistoryofbleedingwerenonsigni2cant.Hisactivatedpartialthromboplastintimewasfoundtobeprolongedinthe emergency department. Further workup with coagulation studies showed decreased factor VIII, vWF antigen, and vWF:ristocetincofactorassay,andnegativeBethesdaassay,indicatingacquiredvonWillebranddisease.Immuno8uorescenceto2ndanunderlying etiology was suggestive of MGUS. Management of AvWD depends on controlling active bleeding and treating theunderlying cause. He was treated with factor VIII, haemate-p, rituximab, two cycles of IVIg, and three weeks of oral steroids.
Keywords :
Acquired von Willebrand Disease Associated , Monoclonal Gammopathy , Unknown Significance , AvWD
