Advanced Alveolar Soft Part Sarcoma Treated withPazopanib over Three Years

Alveolar soft part sarcoma (ASPS) is a rare malignant tumor that generally occurs in adolescents and young adults. It progresses slowly,but lung and brain metastases often occur in the early phase of the clinical course, and chemotherapy has been reported as not beingeffective for ASPS. Pazopanib is a multitargeted tyrosine kinase inhibitor that has been clinically available from November 2012 inJapan. *is is a case report of a patient presented with multiple lung metastases and unresectable primary abdominal ASPS. We initiallytreated this patient by systemic chemotherapy with combination use of ifosfamide and doxorubicin. Stable disease was observedwithout any objective response. *en, we 8nally started to administrate pazopanib 800 mg/day. After 25 months of pazopanibadministration, slight tumor reduction and a decrease of enhancement were observed. Objective responses were achieved for both theprimary tumor and metastatic lung tumor; however, a newly developed brain metastasis was subsequently identi8ed. Based on thiscase, pazopanib appears effective against ASPS, except for brain metastases. *is case suggests that pazopanib may be useful as a 8rst-line drug against unresectable ASPS and that longitudinal assessment of brain metastasis should be performed in similar cases