Primary Pulmonary Malignant Melanoma: Report ofan Important Entity and Literature Review

Malignant melanoma involving the respiratory tract is nearly always metastatic in origin, and primary tumors are extremely rare.Published data on primary pulmonary malignant melanomas are limited. Up to now 40 relevant cases have been reported in theEnglish literature. Herein, we report a case of a 56-year-old female patient who presented with intracranial metastases due toprimary pulmonary melanoma. She underwent bronchoscopy and died 5 months after the initial diagnosis despite the administeredbiochemotherapy and subsequent immunotherapy. To establish the diagnosis of primary pulmonary malignant melanoma, anyextrapulmonary origin was excluded by detailed examination and radiographic imaging. Moreover, an extensive review of theliterature regarding this rare entity has been performed.