Author/Authors :
Reza, Nosheen Division of Cardiovascular Medicine - Center for Inherited Cardiovascular Disease - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Chowns, Jessica L. Division of Cardiovascular Medicine - Center for Inherited Cardiovascular Disease - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Marzolf, Amy Division of Cardiovascular Medicine - Center for Inherited Cardiovascular Disease - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Kim, Jessica Division of Cardiovascular Medicine - Center for Inherited Cardiovascular Disease - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Levine, Lisa D. Department of Obstetrics and Gynecology - Maternal and Child Health Research Center - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Supple, Gregory Cardiac Electrophysiology Section - Division of Cardiovascular Medicine - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA , Tiku Owens, Anjali Division of Cardiovascular Medicine - Center for Inherited Cardiovascular Disease - Perelman School of Medicine - University of Pennsylvania, Philadelphia, PA, USA
Abstract :
Lamin A/C cardiac disease is a genetic cardiomyopathy and arrhythmia syndrome caused by alterations in the function of the
nuclear lamin A and C proteins. It is inherited in an autosomal dominant manner and usually presents in mid- to late
adulthood with atrioventricular conduction abnormalities, atrial and ventricular arrhythmias, biventricular dysfunction, and
advanced heart failure. While rare, women of childbearing age can exhibit an aggressive disease course, and appropriate
risk stratification and management are critical. Here, we present a case of newly diagnosed lamin A/C cardiac disease in a
pregnant woman.
