Author/Authors :
Zeitjian, Vicken Department of Cardiovascular Diseases - University of Texas San Antonio Health Science Center, Floyd Curl Dr. San Antonio, TX, USA , Moazez, Carmel Department of Internal Medicine - Creighton University Maricopa Medical Center, Phoenix, AZ, USA , Arslan, Waqas Department of Hematology and Oncology - Creighton University Maricopa Medical Center, Phoenix, AZ, USA , Saririan, Mehrdad Department of Cardiovascular Diseases - Creighton University Maricopa Medical Center, Phoenix, AZ, USA
Abstract :
Arsenic trioxide (ATO) is commonly known to cause QT prolongation with resultant ventricular tachycardia (VT). VT,
independent of QT prolongation, can be a complication of ATO. We present a 46-year-old female who received ATO and
during her hospital course had intermittent nonsustained VT. All usual causes of VT were considered including reduced
EF < 35%, ischemia, electrolyte abnormalities, medications, and genetic polymorphisms; however, no specific cause was
found. After stopping therapy, the episodes of nonsustained VT ceased indicating that there is an association between ATO and VT.
