Author/Authors :
Huben, Marianne Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Gbadamosi, Bolanle Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Ezekwudo, Daniel Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Nayak, Bhadresh Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Yu, Zhou Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Jaiyesimi, Ishmael Beaumont Hospital - Oakland University School of Medicine - Department of Hematology and Oncology - Royal Oak - MI, USA , Gjorgova-Gjeorgjievski, Sandra Beaumont Hospital - Oakland University School of Medicine - Department of Anatomic and Hematopathology - Royal Oak - MI, USA , Xie, Ming Beaumont Hospital - Oakland University School of Medicine - Department of Anatomic and Hematopathology - Royal Oak - MI, USA , Robert, Colvin Beaumont Hospital - Oakland University School of Medicine - Department of Diagnostic Radiology and Molecular Imaging - Royal Oak - MI, USA
Abstract :
Malignant melanoma is responsible for the majority of skin cancer deaths and is increasing in prevalence. Bone marrow (BM)involvement by melanoma is rare in the absence of widespread visceral disease. Here, we report the case of a 30-year-old female whopresented to the hospital with back pain, low-grade fever, and easy bruising. She was found to be bicytopenic and in disseminatedintravascular coagulopathy (DIC). Surprisingly, BM biopsy showed extensive involvement by metastatic malignant melanoma inthe absence of visceral or brain metastasis. The unique presentation of this case and the challenge of management of a potentiallytreatable cancer in a critically ill patient are discussed, alongside a review of published cases of metastatic melanoma in the BMand an exploration of currently available treatment options. The excellent response of our patient to combined immune checkpointinhibitors has yet to be paralleled in the available literature
Keywords :
Effective Immunotherapy , Bone Marrow Metastatic Melanoma Presenting , Disseminated Intravascular Coagulopathy , DIC
