Docetaxel-Induced Systemic Sclerosis with Internal OrganInvolvement Masquerading as Congestive Heart Failure

Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequentinvolvement of internal organs such as lungs, gastrointestinal tract, or kidneys. Docetaxel is a chemotherapeutic agent which hasbeen associated with cutaneous side effects. An uncommon cutaneous side effect of docetaxel is scleroderma-like skin changes thatextend from limited to diffuse cutaneous systemic sclerosis. Several case reports have been published regarding the associationof docetaxel and systemic sclerosis. However, those reports demonstrated the association between docetaxel and scleroderma-likeskin changes without internal organ involvement. Here, we report a case of systemic sclerosis with pulmonary arterial hypertensionand a microangiopathic kidney involvement induced by docetaxel chemotherapy. After an exhaustive literature review, this couldbe the first case of docetaxel-induced systemic sclerosis involving internal organs.