Title of article :
Evaluation of the Expression of the Human Epithelial Receptor 2 (HER2) in Gastric Carcinoma
Author/Authors :
de Moraes Cordts Filho, Roberto Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Kassab, Paulo Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Carolina Lopez Claro, Laura Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , de Medeiros Fracassi, Mabel Tatty Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Colombo-Souza, Patrícia Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Kenji Fukuhara, Daniel Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Rodrigues Thuler, Fábio Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Rodrigues de Freitas Junior, Wilson Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Jirjoss Ilias, Elias Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil , Alberto Malheiros, Carlos Gastric and Obesity Surgery Division - Surgery Department - Santa Casa of Sao Paulo Medical School - S ˜ ao Paulo - SP - Brazil
Abstract :
Objective. To evaluate the HER2 expression on gastric adenocarcinoma from a Brazilian population and also to analyze the relations between the receptor and clinical characteristics, as well as the survival status. Materials and Methods. A retrospective analysis was
conducted from January of 2008 to July of 2012, considering only gastrectomies with curative intent. Tumors were tested for HER2 status using immunohistochemistry. The relation between HER2 status and clinical aspects, surgical findings, and survival were
also analyzed. Results. 222 patients with gastric carcinoma were submitted to surgery during that period, but only 121 (54,5%) were
with curative intention. The immunohistochemistry revealed that 4 patients (3,3%) were HER2-positive, 6 patients (4,9%) HER2-
undetermined, and 111 patients (91,7%) HER2-negative. There was no statistical concordance between HER2 status and survival or the clinical aspects. Conclusion. The HER2 overexpression rate was very low in this Brazilian population sample and cannot be considered as a prognostic factor.
Keywords :
Evaluation , Human Epithelial , Receptor 2 (HER2) , Gastric Carcinoma
Journal title :
The Scientific World Journal
