Title of article :
Chemical Composition and In Vitro Antioxidant, Cytotoxic, Antimicrobial, and Larvicidal Activities of the Essential Oil of Mentha piperita L. (Lamiaceae)
Author/Authors :
da Silva Ramos, Ryan Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil , Lobato Rodrigues, Alex Bruno Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil , Ferreira Farias, Ana Luzia Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil , Carvalho Simões, Ranggel Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil , Tânia Pinheiro, Mayara Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil , dos Anjos Ferreira, Ricardo Marcelo Laboratory of Arthropoda - Federal University of Amapa - Rodovia Juscelino Kubitschek - Km 02 - ´ Jardim Marco Zero - Macapa - AP - Brazil , Mayana Costa Barbosa, Ledayane Laboratory of Arthropoda - Federal University of Amapa - Rodovia Juscelino Kubitschek - Km 02 - ´ Jardim Marco Zero - Macapa - AP - Brazil , Nonato Picanço Souto, Raimundo Laboratory of Arthropoda - Federal University of Amapa - Rodovia Juscelino Kubitschek - Km 02 - ´ Jardim Marco Zero - Macapa - AP - Brazil , Fernandes, João Batista Department of Chemistry - Federal University of Sao Carlos - Washington Luis Highway - Km 235 - SP-310 - ˜ 13565-905 Sao Carlos - SP - Brazil , da Silva Santos, Lourivaldo Laboratory of Chemistry - Federal University of Para - Rua Augusto Corr ´ ea - 01-Setor B ˆ asico - 66075-110 Bel ´ em - PA - Brazil , Moreira da Silva de Almeida, Sheylla Susan Laboratory of Pharmacognosy and Phytochemistry - Federal University of Amapa - Highway Juscelino Kubitschek - ´ Km 02, Macapa - AP - Brazil
Abstract :
The essential oil was obtained by hydrodistillation and the identification and quantification of components were achieved with the use of GC-MS analysis. The antioxidant activity was evaluated by the method of sequestration of DPPH. Essential oils were used for study the cytotoxic front larvae of Artemia salina. In the evaluation of the antimicrobial activity of essential oils, we employed
the disk-diffusion method. The potential larvicide in mosquito larvae of the third stage of development of Aedes aegypti to different concentrations of essential oils was evaluated. The major compounds found in the essential oils of M. piperita were linalool (51.8%) and epoxyocimene (19.3%). The percentage of antioxidant activity was 79.9 ± 1.6%. The essential oil showed LC50 = 414.6 𝜇g/mL front of A. saline and is considered highly toxic. It shows sensitivity and halos significant inhibition against E. coli. The essential possessed partial larvicidal efficiency against A. aegypti.
Keywords :
Chemical Composition , In Vitro Antioxidant , Cytotoxic , Antimicrobial , Larvicidal Activities , Essential Oil , Mentha piperita L. , Lamiaceae
