• Title of article

    Label-Free Imaging of Blood Vessels in Human Normal Breast and Breast Tumor Tissue Using Multiphoton Microscopy

  • Author/Authors

    Chen, Jianxin Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , Xi, Gangqin Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , Chen, Zhong Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , He, Jiajia Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , Ren, Wenjiao Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , Shen, Tingfeng Key Laboratory of Optoelectronic Science and Technology for Medicine of Ministry of Education - Fujian Provincial Key Laboratoryof Photonics Technology - Fujian Normal University - Fuzhou 350007, China , Cao, Ning Department of Plastic Surgery - Zhangzhou Affiliated Hospital of Fujian Medical University- Zhangzhou - 363000 Fujian, China , Guo, Wenhui Department of Breast Surgery - Fujian Medical University unio‎n Hospital - Fuzhou 350001, China , Wang, Chuan Department of Breast Surgery - Fujian Medical University unio‎n Hospital - Fuzhou 350001, China , Kang, Deyong Department of Pathology - Fujian Medical University unio‎n Hospital - Fuzhou 350001, China

  • Pages
    9
  • From page
    1
  • To page
    9
  • Abstract
    Bloodvesselsaretheimportantcomponentsofthecirculatorysystemsthattransportbloodthroughoutthehumanbodyandmaintainthehomeostasisofphysiologicaltissues .Pathologically,bloodvesselsareoftenaffectedbydiseases,leadingtotheformationofunstable,irregular,andhyperpermeablebloodvessels.Inthetumormicroenvironment,abnormalleakageoftumorbloodvesselsisrelatedtothehistologicalgradeandmalignantpotentialoftumorsandmayalsofacilitatemetastasisofcancer.Visualdiagnosisofbloodvesselsisveryimportantforustounderstandtheoccurrenceanddevelopmentofdiseases. Multiphotonmicroscopy(MPM) isapotentiallabel-freediagnostictoolbasedonsecondharmonicgeneration (SHG) andtwo-photonexcitedfluorescence(TPEF).MPMcaneffectivelyobservethemorphologicalchangesofbiologicaltissuesatthemolecularandcellularlevels.Inthiswork,wedemonstratethatlabel-free MPM canbeusedtovisualizethemicrostructureofbloodvesselsinhumannormalbreastandbreasttumortissue. Moreover,MPM canmonitorthechangesofbloodvesselsintumormicroenvironment.TheseresultsshowthattheMPMwillbecomeapromisingtechniqueforclinicianstostudythepropertiesofthemicrostructureofthebloodvessels
  • Keywords
    Label-Free Imaging , Blood Vessels , Human Normal Breast , Breast Tumor Tissue Using Multiphoton Microscopy , TPEE , SHG
  • Journal title
    Scanning
  • Serial Year
    2019
  • Full Text URL
    downloads.hindawi.com/journals/scanning/2019/5192875.pdf
  • Record number

    2613416

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2613416