Author/Authors :
Ma, Huihui Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China , Cao, Xin Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China , Zhang, Jing Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China , Zhou, Yongmei Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China , Luo, Rong Institute of Geriatric Cardiovascular Disease - Chengdu Medical College, Chengdu, Sichuan, China , He, Tao Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China , Tao, Jianhong Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China , Li, Xiaoping Department of Cardiology - Sichuan Provincial People’s Hospital - University of Electronic Science and Technology of China, Chengdu, Sichuan, China
Abstract :
A 32-year-old female with systemic lupus erythematosus (SLE) for more than 7 years, and long-term treatment with
cyclophosphamide, cyclosporine, methotrexate, and tacrolimus, later found to be combined with hypertrophic cardiomyopathy
(HCM) for one year. The patient denied a family history of cardiomyopathy and sudden cardiac death (SCD).
Echocardiography suggested that uneven thickening of the left ventricle (LV), mainly in the lower middle segment. Cardiac
magnetic resonance (CMR) showed that the walls of the left ventricular (LV) were significantly thickened, as about 21 mm,
mainly in the middle and lower segments. Genetic tests showed no known or suspected pathogenic variations were found and
no significant enhancement in CMR, so secondary HCM was diagnosed clinically. After symptomatic treatment, the patient was
discharged, and long-term follow-up was conducted. The diagnosis of HCM, which combined with SLE or second to usage of
tacrolimus, was based on symptoms, echocardiography, and CMR; no endomyocardial biopsies were performed.
Keywords :
Systemic Lupus , Erythematosus Complicated , Hypertrophic , Cardiomyopathy
