Title of article :
An Overview of the Application of Poly(lactic-co-glycolic) Acid (PLGA)-Based Scaffold for Drug Delivery in Cartilage Tissue Engineering
Author/Authors :
Pourentezari ، Majid Department of Anatomy and Molecular Biology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences , Dortaj ، Hengameh Department of Tissue Engineering and Applied Cell Science - Shiraz University of Applied Medical Science and Technologies , Hashemibeni ، Batool Department of Anatomical Sciences and Molecular Biology - Isfahan University of Medical Sciences , Yadegari ، Maryam Department of Anatomy and Molecular Biology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences , Shahedi ، Abbas Department of Anatomy and Molecular Biology - Faculty of Medicine - Shahid Sadoughi University of Medical Sciences
Abstract :
Poly(lactic-co-glycolic) acid (PLGA) has attracted a considerable amount of interest for biomedical application due to its biocompatibility, tailored biodegradation rate (depending on the molecular weight and copolymer ratio), approval for clinical use in humans by the U.S. Food and Drug Administration (FDA), the potential to change surface properties to create better interaction with biological materials and being suitable for export to countries and cultures where planting products with animals is unusable. For commercial use and research, PLGA has been widely studied to control small molecule drugs, proteins, and other macromolecules. This study aims to review the studies that used PLGA scaffolding and its composites as a scaffold and drug delivery in cartilage tissue engineering. It is concluded from the results that the PLGA scaffold as a synthetic scaffold, when combined with natural scaffolds or hybrids, strengthens its biological properties and performs its function better.
Keywords :
Cartilage , Drug delivery , PLGA , Scaffold , Tissue engineering
Journal title :
International Journal of Medical Laboratory
Journal title :
International Journal of Medical Laboratory
