Title of article :
Influence of Chronic Alcohol Use on Osteoblastic Differentiation of Bone Marrow Cells, Bone Properties, and Hepatic and Renal Morphology of Rats
Author/Authors :
de Sousa, Michelle Cardoso School of Dentistry-Funvic - Faculty of Pindamonhangaba - Braz Cubas University - Mogi das Cruzes - SP - Brazil , da Cruz Vegian, Mariana Raquel Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil , Alves Biserra, Matheus Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil , Almeida Costa, Bruno César Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil , Afonso Camargo, Samira Esteves Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil , de Mello Rode, Sigmar Department of Prosthodontic and Dental Material - Institute of Science and Technology - Sao Paulo State University (UNESP) - Sao Jose dos Campos - SP, Brazil , Judica Ramos, Carolina Department of Social Dentistry and Children’s Clinic - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP, Brazil , de Oliveira, Luciane Dias Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil , de Vasconcellos, Luana Marotta Reis Department of Bioscience and Oral Diagnosis - Sao Jose dos Campos Institute of Science and Technology - ˜ Universidade Estadual Paulista (UNESP) - Av. Engenheiro Francisco Jose Longo - 777 - S ´ ao Jos ˜ e dos Campos 12245-000 - SP - Brazil
Abstract :
Chronic alcohol exposure can afect the osteoblastic activity and the proliferation and diferentiation of cells due to its toxic effect, which can affect negatively bone repair and bone microarchitecture. Te aim of this study was to evaluate the effects of chronic use of 20% alcohol on rats regarding osteoblastic diferentiation, extrinsic and intrinsic properties of the tibia, and hepatic and
renal morphology. Wistar rats were divided into three groups (=9) in accordance with a 24-week diet. Afer euthanasia, kidneys, liver, and tibias were removed for analysis and femurs mesenchymal cells were collected. Te results showed that chronic use of
20% alcohol infuenced neither the alkaline phosphatase production nor total protein ( > 0.05) in rats, with similar formation
of nodules in all groups ( > 0.05). However, signifcant changes in the liver and kidneys and adverse efects on the mechanical
properties of the tibia were observed. According to the results, it can be concluded that the chronic use of alcohol for 24 weeks had
no negative infuence on the activity and diferentiation of osteoblasts, but the mechanical properties of the tibia were impaired and the organs responsible for metabolism and excretion were also affected due to the consumption of alcohol.
Keywords :
Influence , Chronic Alcohol , Osteoblastic Differentiation , Bone Marrow Cells , Bone Properties , Hepatic , Renal Morphology , Rats
Journal title :
The Scientific World Journal
