Author/Authors :
Sarat, Gummadapu Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India , Priyanka, Nuthalapati Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India , Purna Venkata Prabhat, Meka Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India , Raja Lakshmi, Chintamaneni Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India , Mulk Bhavana, Sujana Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India , Ayesha Thabusum, Dharmavaram Department of Oral Medicine & Radiology - Drs. Sudha and Nageswara Siddhartha Institute of Dental Sciences, Chinoutpalli, Gannavaram Mandal, Andhra Pradesh, India
Abstract :
Hypophosphatemic rickets (HR) is a type of hereditary rickets characterized by persistent hypophosphatemia and hyperphosphaturia. The most predominant type is inherited in an X-linked fashion and caused by mutation in the gene encoding the phosphateregulating endopeptidase homolog, X-linked (PHEX), identified in 1995. The X-linked hypophosphatemic (XLH) rickets is a rare
hereditary metabolic disorder with a prevalence of 1 in 20,000 and causes deficient calcification of mineralized structures such as
bones and teeth resulting in dental problems in terms of delayed eruption, spontaneous periapical infections, and exfoliation. We
report one such unique case of hypophosphatemic vitamin D-resistant rickets in siblings exhibiting classical features of rickets with
emphasis on its treatment and dental considerations.
