Author/Authors :
Wang, Shujuan Harbin Engineering University - Harbin, China , Song, Ping Department of Dermatology - Guang’anmen Hospital - China Academy of Chinese Medical Sciences - Beijing, China , Ma, Rong Harbin Engineering University - Harbin, China , Wang, Yanzhong School of Population Health & Environmental Sciences - Faculty of Life Science and Medicine - King’s College London - London, UK , Yu, Bin Department of Dermatology - Guang’anmen Hospital - China Academy of Chinese Medical Sciences - Beijing, China , Wang, Min Harbin Engineering University - Harbin, China , Wang, Meiqi Harbin Engineering University - Harbin, China , Shen, Jihong Harbin Engineering University - Harbin, China , Dai, Yuntao Harbin Engineering University - Harbin, China , Wang, Yuming Department of Dermatology - Guang’anmen Hospital - China Academy of Chinese Medical Sciences - Beijing, China , Xie, Wanqing Harbin Engineering University - Harbin, China
Abstract :
Chronic spontaneous urticaria (CSU) is a common skin disease which symptom is local pruritus and pain. In medicine, researchers
take a certain point that the brain is the control center of CSU, but in previous experiments, the researchers found that cerebellum
also had a certain effect on CSU. In order to find out the influence of CSU in the brain and cerebellum, we collected the brain
resting-state fMRI data from 40 healthy controls and 32 CSU patients and used DPABI to preprocess. We calculated the
entropy values of five scales by using multiscale entropy (MSE) and the average entropy values of two groups’ BOLD signals; 15
regions with significant differences were found which not only had a more detailed impact in the brain but also had an impact
in the cerebellum, such as precentral gyrus, lenticular putamen, and vermis of cerebellum. In addition, we found that compared
with the healthy controls, the entropy values of CSU patients showed two trends which need further study. The advantage of
our experiment is that the multiscale entropy value is used to get more influence regions of CSU in the brain and cerebellum.
The results of this paper may provide some help for the pathological study of CSU.
Keywords :
Characteristic , Spontaneous , Multiscale Entropy , CSU
