Author/Authors :
Yamagata, Kenji Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Nagai, Hiroki Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Baba, Osamu Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Uchida, Fumihiko Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Kanno, Naomi Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Hasegawa, Shogo Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Yanagawa, Toru Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan , Bukawa, Hiroki Department of Oral and Maxillofacial Surgery - Institute of Clinical Medicine - Faculty of Medicine - University of Tsukuba, Japan
Abstract :
Reports of brain abscesses caused by medication-related osteonecrosis of the jaw (MRONJ) are very rare. We here present the case
of a 76-year-old man with terminal-stage prostatic carcinoma and a brain abscess caused by MRONJ at the maxilla. The patient
had been treated with zoledronic acid and denosumab for bone metastasis. For the brain abscess, an antibiotic regimen based
on ceftriaxone and metronidazole and a sequestrectomy contributed to a successful outcome. In the case of maxillary MRONJ
extending to the maxillary sinus, active resection of the infected bone should be considered to prevent the spread of the infection
beyond the maxillary sinus, into the ethmoid sinus, and into the brain.
