Title of article
Non-bulky Lesions in Human DNA: The Ways of Formation, Repair, and Replication
Author/Authors
Ignatov, A.V Institute of Molecular Genetics of Russian Academy of Sciences, Russia , Bondarenko, K.A Institute of Molecular Genetics of Russian Academy of Sciences, Russia , Makarova, A.V Institute of Molecular Genetics of Russian Academy of Sciences, Russia
Pages
15
From page
12
To page
26
Abstract
DNA damage is a major cause of replication interruption, mutations, and cell death. DNA damage is removed by several types of repair processes. The involvement of specialized DNA polymerases in replication provides an important mechanism that helps tolerate persistent DNA damage. Specialized DNA polymerases incorporate nucleotides opposite lesions with high efficiency but demonstrate low accuracy of DNA synthesis. In this review, we summarize the types and mechanisms of formation and repair of non-bulky DNA lesions, and we provide an overview of the role of specialized DNA polymerases in translesion DNA synthesis
Keywords
DNA translesion synthesis , DNA repair , DNA damage
Journal title
Acta Naturae
Serial Year
2017
Full Text URL
Record number
2615671
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