Author/Authors :
Markov, O.V Institute of Chemical Biology and Fundamental Medicine SB RAS, Russia , Mironova, N.L Institute of Chemical Biology and Fundamental Medicine SB RAS, Russia , Vlassov, V.V Institute of Chemical Biology and Fundamental Medicine SB RAS, Russia , Zenkova, M.A Institute of Chemical Biology and Fundamental Medicine SB RAS, Russia
Abstract :
The routine methods used to treat oncological diseases have a number of drawbacks, including non-specific action and severe side effects for patients. Furthermore, tumor diseases are associated with a sup-pression of the immune system that often leads to the inefficiency of standard treatment methods. The develop-ment of novel immunotherapeutic approaches having specific antitumor action and that activate the immune system is of crucial importance. Vaccines based on dendritic cells (DCs) loaded with tumor antigens ex vivo that can activate antitumor cytotoxic T-cell responses stand out among different antitumor immunotherapeutic approaches. This review is focused on analyzing different methods of DC-based vaccine preparation and current research in antitumor DC-based vaccines using animal tumor models and in clinical trials.
Keywords :
clinical trials , murine tumor models , delivery of tumor antigens , antitumor vaccines , dendritic cells
